What does macrophage colony stimulating factor do?
Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that regulates the proliferation, differentiation, and functional activation of monocytes. Normally detected in human serum, M-CSF plays an important role in enhancing the effector functions of mature monocytes and macrophages.
What colony stimulating factor is involved with granulocyte macrophage production?
GM-CSF
Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first identified in mouse lung tissue-conditioned medium following lipopolysaccharide injection into mice by its ability to stimulate proliferation of mouse bone marrow cells in vitro and generate colonies of both granulocytes and macrophages 1.
What is recombinant granulocyte macrophage colony stimulating factor?
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine.
What is anti GM-CSF?
Background: The role of anti-granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies as a diagnostic marker in idiopathic pulmonary alveolar proteinosis (iPAP) remains unclear. Methods: Anti-GM-CSF antibodies were detected in blood and bronchoalveolar lavage fluid (BAL) fluid in 13 patients with iPAP.
What do colony stimulating factors do?
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hematopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell, usually white blood cells.
What is granulocyte colony stimulating factor used for?
Granulocyte colony-stimulating factor is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant.
Where is GM-CSF found?
GM-CSF is a colony-stimulating factor that regulates growth and differentiation of hematopoietic cells. The lung is a major source of GM-CSF and most pulmonary cells are able to synthesize this cytokine in response to various stimuli [4].
What is the difference between G CSF and GM CSF?
G-CSF induces the appearance of colonies containing only granulocytes, while GM-CSF gave colonies containing both granulocytes and macrophages. Generation of G-CSF (genomic nomenclature: Csf3) and G-CSF Receptor (Csf3r) knockout mice confirmed that G-CSF critically drives granulopoiesis(7).
What is PAP lung disease?
Pulmonary alveolar proteinosis (PAP) is a syndrome, a set of symptoms and signs – not a single disease, in which surfactant in alveoli builds up slowly. This blocks air from entering alveoli and oxygen from passing through into the blood, which results in a feeling of breathlessness (dyspnea).
Which of the following is a major colony-stimulating factor?
COLONY STIMULATING FACTORS Family members include macrophage-CSF (M-CSF), granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF), and interleukin-3 (IL-3).
Which medication is an example of a colony-stimulating factor?
Granulocyte – colony stimulating factor (G-CSF) is another name for filgrastim. In some cases, health care professionals may use the trade name Neupogen, Granix or Zarxio when referring to the generic drug name filgrastim.
Can G-CSF cause leukemia?
G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.